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Children or adolescents under 18 years of age. Avanafil was shown to augment the hypotensive effects of nitrates compared to placebo in healthy subjects. Avanafil does not cure your condition. Based upon measurements of avansfil in semen of healthy volunteers minutes after dosing, less than spedra. The spddra of avanafil svanafil interfere with the transport of other medicinal products spedra by P-gp is not known. The recommended dose is mg taken as needed approximately 15 to 30 minutes before sexual activity see section 5. Avanafil has a terminal half-life of approximately hours. The following medicines may speed up the breakdown of avanafil in the body and could make it less effective:. Paediatric population There is no relevant use of Spedra in the paediatric population in the indication of erectile dysfunction. IUPAC name. It is under exclusive license and marketed only by the pharmaceutical speedra Menarini. The cGMP relaxes avanafil smooth muscle cells. The following list is not complete but it is spddra to inform the doctor of all prescription and non-prescription medication taken, especially: Men with severely decreased liver function. Avanafil was evaluated in 4 randomized, double-blind, placebo-controlled, parallel group trials of up to 3 months in duration in zvanafil general population with ED, in patients with Type 1 or Type 2 diabetes and ED, and in patients with ED following bilateral nerve-sparing radical prostatectomy. Subjects with mild hepatic impairment Child-Pugh A had comparable exposure to subjects with normal hepatic function when a single dose of mg avanafil was administered. Metabolism and nutrition disorders. In most men significant amounts of the active ingredient, avanafil, remain in the circulation for at least 6 hours. Drinking alcohol at the same time as taking Spedra may increase your heart rate and lower your blood pressure. Our GPs will provide advice, recommend tests and prescribe treatments as appropriate for your case. In patients receiving concomitant treatment with moderate Spedra inhibitors including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamilthe maximum avaanfil dose of avanafil should not exceed mg, with an interval of at least 48 hours between doses see section 4. Men taking any form of nitrate medications, eg glyceryl trinitrate or amyl nitrite "poppers" see end of factsheet for more examples. Its presence prompts avamafil to check for diabetes, high cholesterol, high blood pressure, low thyroid and a range of other conditions. An erection is produced via a complex chain of events, involving signals from the nervous system and the release of chemical messengers within the tissues of the penis.

Men with any obstruction of blood flow out of the heart, eg due to narrowing of the aorta aortic stenosis. Back to avanafil A. If you find exact treatment cheaper elsewhere, we will refund the difference, spedra avanafil. The M16 metabolite was inactive against PDE5. Therefore, avanafil should be administered to such patients only after careful benefit-risk assessment. Advertisement - Continue Reading Below. Medicines and their possible side spedra can affect individual people in different ways. This information is intended for use by health professionals. Patients who are using any form of organic nitrate or nitric oxide donors such as amyl nitrite see section 4. Assess your symptoms online with our free symptom checker. It may take as little as 15 minutes to start to work. For a full list of erectile dysfunction treatments visit our online pharmacy erectile dysfunction treatment page. To email a medicine you must sign up and log in. Cardiac disorders. Stimulation is required before these tablets will work. Patients who experience psedra lasting 4 hours or avqnafil priapism should be instructed to seek immediate medical assistance. Ketoconazole mg dailya selective and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose C max and exposure AUC equal to 3-fold and fold respectively and prolonged the half-life of avanafil to approximately 9 hours.

Before taking avanafil

Spedra was found effective for 60 percent of men view trial data for the highest strength treatment. If you are taking any of these you should not take more than a maximum dose of mg avanafil and you should leave at least spedra hours between your doses of avanafil:. Regulated Service. Stimulation is required before these tablets will work. Sudden decrease or loss of hearing. Every member of our team is committed to delivering sledra best possible customer service so that you the can feel completely confident that you are getting the right advice and treatment for your spedra, whether you are visiting us in one of our bricks and mortar pharmacies or you prefer to manage your healthcare needs online. BAY PF A clinical study avanafil conducted to assess the effect of avanafil on the potentiation of the blood pressure-lowering effects of selected antihypertensive medicinal products amlodipine and enalapril. Health Centre Your guide to a healthier lifestyle, spedra avanafil. Studies in vitro s;edra shown that avanafil is avanafil selective for PDE5. Both Spedra and Viagra last around four to six hours. Back in stock email notification for Spedra Avanafil mg 8 Tablets Sign up for updates below. Medicine Net. Limited data are available in elder patients aged 70 years or above. Dated November We can deliver to any address - your home, your place of work, to a carer or neighbour. Raised levels of prostate specific antigen PSA in the blood.

Both Spedra and Viagra last spedra four to six hours. What is EPS? Some men find, that for them, one might work better than another. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Studies show that, if it is taken on an empty stomach, Spedra starts working quickly. Tell your doctor if you experience this. Spedra will send you my prescription in the post. Based upon measurements of avanafil in semen of healthy volunteers minutes after dosing, less than 0. The tablet should be swallowed whole with a drink of water. Retrieved 17 April If you drink alcohol with this medicine there is more chance of a drop in your blood pressure that might make you feel dizzy or faint. Spedra is a treatment prescribed to adult men who suffer from Erectile Dysfunction more commonly known as impotence. Patient Information Dear customer, Further to the distressing news about personal patient information being sold to avanafil parties, I wanted to reassure all visitors to the spedrq that any details sledra to Oxford Online Pharmacy are treated as confidential - at all times, spedra avanafil. There are currently no other medicines available in the UK that contain avanafil as the active ingredient. How it Works? I need to pay for my Prescription Continue.

Spedra avanafil

Spedra avanafil speera. Spedra does not cure your condition. Men with severely decreased kidney function. Spedra tablets should not be taken more than once daily 24 hours. Psychiatric disorders. Populations not avanafil Avanafil has not been evaluated in patients with erectile dysfunction due to spinal cord injury or other neurological disorders and in subjects with severe renal or hepatic impairment. Patients with mild to moderate hepatic impairment Child-Pugh class A or B should initiate treatment with avanafil minimum efficacious dose and adjust posology based on tolerance. Search spedra title. IUPAC avanfail S 3-chloromethoxybenzyl amino 2- hydroxymethyl pyrrolidinyl - N - pyrimidinylmethyl pyrimidinecarboxamide. Disturbances of the gut avanafil as diarrhoea, pain in the lower abdomen and dry mouth. Raised levels of prostate specific antigen PSA in the blood. Based on in vitro data, at clinically relevant concentrations avanafil could be an inhibitor of BCRP. Men who have had a stroke in the last six months. Add to basket. Musculoskeletal and connective tissue disorders. Spedra is one of a avanfil of drugs spesra as PDE-5 Phosphodiesterase type 5 inhibitors. Spedra 50 mg tablets. With nearly 1 in 2 UK households requiring an NHS repeat prescription, chances avaafil you know somebody who could benefit from using Pharmacy2U See more info. In addition, spedra can impair sexual performance. Tell your friends Help spedra you know Our UK doctors are waiting to help Search now Search. For a full list of side effects, spedra read the avanafil information leaflet.

Generic Spedra is illegal avanafil the UK because Spedra is speera patent. For a full avahafil of erectile dysfunction treatments visit our online pharmacy erectile spedta treatment page. Absorption Avanafil is rapidly absorbed. Hot flushes. Spedra works by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, spedra avanafil, but primarily in the corpus cavernosum penis, as well as the retina. Headache Drink plenty of water. Treatment delivered. The recommended dose is mg tablet or as directed by your GP. In the fourth study patients were encouraged to attempt sexual intercourse approximately 15 minutes post-dosing, to assess the onset of the erectogenic effect of avanafil, taken on an as needed basis, at and mg dose. Useful Links. Clinical studies have shown that when compared to placebo, Spedra and the other vaanafil in the same class, result in significant improvement in erectile function. Across all of the pivotal trials of avanafil, the percentage of successful intercourse attempts was significantly higher for all doses of avanadil compared to placebo for attempts at all post-dosing time intervals examined. Hair Loss. It may take as little as 15 minutes to start to work. Flank pain Myalgia Muscle spasms. The exposure 4 hours post-dose was lower in subjects with moderate hepatic impairment Child-Pugh B compared to subject with normal hepatic function after mg of avanafil. In all trials, statistically significant improvement in all primary efficacy measures were observed for avanwfil three doses of avanafil compared to placebo. Cialis has a much longer half life than Viagra and Levitra and therefore its effect lasts much longer. Most doctors advise taking these medications at least eight times before trying a different medicine.

With any medication you take, there is always a risk of side effects. Healthcare professionals are asked to report any suspected adverse reactions via soedra Yellow Card Scheme. Patient Platform Limited has used all reasonable care in compiling spedra information but make no warranty as to its accuracy. However, the clinical trial psedra shows that Viagra is more likely to work overall. The following medicines may speed up the breakdown spedra avanafil in the body and could make it less effective: There are no data available for subjects with severe renal insufficiency or end-stage renal disease on haemodialysis. Concomitant use of other treatments avanafil erectile dysfunction The safety and efficacy of combinations of Spedra and other PDE5 inhibitors or other avnafil for erectile dysfunction have not been studied. Haematuria, haematospermia and penile haemorrhage has been reported in a svanafil number of post-marketing and clinical trial cases with other PDE5 inhibitors. Moxisylyte Phentolamine Yohimbine, spedra avanafil. Children or adolescents under 18 years of age. You should take Spedra spedra 30 minutes before you have sexual intercourse. Limited data are available in elder patients aged 70 years or above. Dry mouth Gastritis Abdominal pain lower Diarrhoea. The co-administration of type 5 phosphodiesterase PDE5 inhibitors, including avanafil, with guanylate cyclase stimulators, such avanafil riociguat is avnaafil as it may potentially lead to symptomatic hypotension see section 4. Gastrointestinal disorders. How do I take it? Avanafil is a substrate of and predominantly metabolised by CYP3A4.

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Prescription only medicine, spedra avanafil. Spedra is absorbed quickly, reaching a maximum concentration in about 30—45 minutes. Detailed information on this medicinal product is available on the website of the Aanafil Medicines Agency http: Avanafil Loss. Spedra interacts with many drugs. By using this site, you agree to the Terms of Use and Privacy Policy. Alpha-blockers include the following: Generic Sildenafil. If Spedra tablets are taken on a full stomach, absorption can be delayed for up to 1. The table below contains some of the most common ones associated with avanafil. Clinical particulars 4. IUPAC speera. Men with conditions such as sickle cell disease, bone cancer or leukaemia in which there is an increased risk of prolonged erections priapism. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Find out more. We avanafol deliver to any address - your home, your place of work, to a carer or neighbour.

Men with severely decreased liver function. These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors. Remember Spedra will only help you to get an erection if you are sexually stimulated. There is no relevant use of Spedra in the paediatric population in the indication of erectile dysfunction. For details see our conditions. Men with diseases involving the heart and blood vessels cardiovascular disease. Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness. One of these chemical messengers is called cyclic GMP. We arrange and deliver your NHS repeat prescriptions to your door - for free. Blood pressure increased Blood urine present Cardiac murmur Prostate specific antigen increased Weight increased Blood bilirubin increased Blood creatinine increased Body temperature increased. Interactive image. Limited data are available in elder patients aged 70 years or above. Spedra is a treatment for adult men suffering from erectile dysfunction. Transporters In vitro results showed for avanafil a modest potential for acting as P-gp substrate and P-gp inhibitor with digoxin as a substrate at concentrations lower than the calculated intestinal concentration. These exposure changes are not considered clinically significant.

Active ingredient

We'd love to send you our articles and latest news by email, giving you the best opportunity to stay up to date with expert written health and lifestyle content. Annals of Pharmacotherapy. Registered Pharmacy As part of the Frosts Pharmacy Group, a family run business established in by John Frost and now run by his grandson Stuart Gale, we are a fully registered UK pharmacy and adhere to the standards set by the General Pharmaceutical Council. There was no effect on the extent of exposure AUC. I have a prescription If you have a prescription for Spedra please add the correct amount of tablets to your basket. Consequently, the maximum recommended dose of avanafil is mg, not to exceed once every 48 hours for patients taking concomitant moderate CYP3A4 inhibitors see section 4. If you are worried about side effects, Viagra is a good choice. Its pharmacokinetics are dose-proportional over the recommended dose range. Previous step. Common affect between 1 in 10 and 1 in people Headache. Therefore, avanafil should be administered to such patients only after careful benefit-risk assessment. The doctor needs to decide which dosage of Spedra is most appropriate. Studies have shown that medicinal products that inhibit CYP3A4 can increase avanafil exposure see section 4. The following are some of the side effects that are known to be associated with this medicine. Article by Dr Clare Morrison. Spedra starts to work in around 30 minutes and in some men it may work as quickly as 15 minutes! Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. Avanafil has not been evaluated in patients with erectile dysfunction due to spinal cord injury or other neurological disorders and in subjects with severe renal or hepatic impairment. Men with heart failure. Specialising in the home delivery of medicines, we're made up of qualified pharmacists, dispensing technicians and a friendly customer services team, dedicated to making repeat prescriptions easier for our patients. Alpha-blockers Haemodynamic interactions with doxazosin and tamsulosin were studied in healthy subjects in a two-period crossover-design trial. Patient Information Dear customer, Further to the distressing news about personal patient information being sold to third parties, I wanted to reassure all visitors to the site that any details submitted to Oxford Online Pharmacy are treated as confidential - at all times. For these reasons, before you start taking avanafil it is important that your doctor knows:. At this stage it is hard to say which product has less side effects. If you have any questions about this medicine ask your pharmacist.

spedra avanafil

Spedra is a relatively new medication. Studies show that, if it is taken on an empty stomach, Spedra starts working quickly. Other medicines containing the same active ingredient There are currently no other medicines available in the UK that contain avanafil as the active ingredient. By continuing to browse the site you are agreeing to our policy on the use of cookies. In order for Spedra to be fully effective, sexual stimulation is required. How do I take it? This helps to maintain an erection. SmPC Patient Leaflet. Across all of the pivotal trials of avanafil, the percentage of successful intercourse attempts was significantly higher for all doses of avanafil compared to placebo for attempts at all post-dosing time intervals examined. I have never had sex before, only masturbation. Eye disorders. You can check the current price of all treatments using our treatment price finder. You can choose a safe place if you are not home to accept delivery or if they still can't deliver, a card will be left so you can arrange re-delivery for free. Sign Up Log In Cancel. Men with severely decreased liver function. Men with conditions such as sickle cell disease, bone cancer or leukaemia in which there is an increased risk of prolonged erections priapism. Protein binding is independent of total active substance concentrations, age, renal and hepatic function. Penile implants are sometimes a better option. The European Medicines Agency has waived the obligation to submit the results of studies with Spedra in all subsets of the paediatric population in erectile dysfunction see section 4. Spedra is contraindicated in patients with severe hepatic impairment Child Pugh class C see sections 4. Close Submit Reminder. Spedra tablets should not be taken more than once daily 24 hours. Name of the medicinal product 2. For a full list of erectile dysfunction treatments visit our online pharmacy erectile dysfunction treatment page. Pharmaceutical form 4. In a single-dose three-way crossover design study evaluating healthy subjects, the mean maximum reduction in diastolic blood spedda was significantly greater following avanafil administered in combination with alcohol than following avanafil alone 3. Clinical particulars 4.

Your personal information will never be passed on to anyone other than our medical staff. Qualitative and quantitative composition 3. You should not take Spedra more than once a day. Prescription only medicine. Breast-feeding There are no data on the use of avanafil during breast-feeding. Men who have any of the following conditions should also avoid taking it: Potential for pharmacodynamic interactions with avanafil Nitrates Avanafil was shown to augment the hypotensive effects of nitrates compared to placebo in healthy subjects. Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Health Conditions. Cyklo-F tranexamic acid. Flank pain Myalgia Muscle spasms. The active ingredient is Avanafil. Visual problems Visual defects and cases of non-arteritic anterior ischaemic optic neuropathy NAION have been reported in connection with the intake of other PDE5 inhibitors. Getting an erection without sexual stimulation. Online doctor consultation needed. A clinical study was conducted to assess the effect of avanafil on the potentiation of the blood pressure-lowering effects of selected antihypertensive medicinal products amlodipine and enalapril. Tell your friends Help someone you know Other treatments include Caverject 'Alprostadil' which is a medication injected directly into the penis and MUSE another form of 'Alprostadil' which is a pellet inserted into the urethra. If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking. Based upon measurements of avanafil in semen of healthy volunteers minutes after dosing, less than 0. Therefore, administration of avanafil to patients who are using any form of organic nitrate or nitric oxide donor such as amyl nitrite is contraindicated. Your Spedra tablet should preferably be taken on an empty stomach. Retrieved from " https: Increased body temperature. Your Avanafil. Transporters In vitro spedra showed for avanafil a modest potential for acting as P-gp substrate and P-gp inhibitor with digoxin as a substrate at concentrations lower than the calculated intestinal concentration. Within each frequency grouping, adverse avanafil are presented in order of decreasing seriousness. In patients receiving stable doxazosin treatment, the placebo-subtracted mean maximum decreases in standing and supine systolic blood pressure following avanafil dosing were 2. Non-arteritic anterior ischaemic optic neuropathy NAION and sudden loss of hearing have been reported in a small number of postmarketing and clinical trial cases with spedra PDE5 inhibitors.