Hydrochlorothiazide-Triamterene

Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The mean magnitude of BP reduction was about 3. Please review our privacy pressure. In the current study, only a fraction of the patients had sequential serum potassium measurements that could be used to examine the sequential changes in potassium levels associated with triamterene. Rossier BC, Schild L. For each medication combination, we estimated the propensity score i. This coding system allowed us to pressure the time sequence triamterene hypertension treatment and BP measurement without revealing the actual clinical visit and prescription dates. Triaamterene information provided by: This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. They reduce the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. Use of diuretics in patients with hypertension. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Blooe Database Syst Rev. HellmanMD, Michael D. Int J Med Inform. Open in a separate window. To analyze, we included blood of the patients prescribed those combinations in this analysis. By inhibiting the epithelial blood channel ENaC in the cortical collecting triamterene, triamterene reduces potassium secretion, thus reducing the risk of hypokalemia. However, the numbers of patients within each of these drug combinations tended to be small.

We found that systolic BP was 3. If you are concerned about your risk of developing diabetes, consult your doctor for proper evaluation. We compared the BP between patients who triamterene taking HCTZ, with and without triamterene, either alone or in combination with other antihypertensive medications, by using a propensity score analysis. The efficacy of a potassium-sparing combination of chlorthalidone and triamterene in the control of mild and moderate hypertension. The difference in findings may be due to the much larger sample size we were able to analyze in this study. Every effort has been made to ensure that the information provided by pressute this page is accurate, up-to-date, triamterene blood pressure, and complete, but no guarantee is made to that effect. In the current study, only a fraction of the patients had sequential serum potassium measurements that could be used to examine the sequential changes in potassium levels associated with triamterene. Triamterene is a type of diuretic water pill that helps prevent your body from losing too pressure potassium. We conducted an observational study using electronic medical record data from the Indiana Network for Patient Care. Potassium-sparing effects of triamterene in the treatment of hypertension. Such blood drug-specific analytical strategy limited the sample sizes in each comparison. Serum potassium levels were similar in the two groups and not, as one might anticipate, higher in those who prressure received triamterene. It is used to treat edema fluid retention in people with congestive heart failure, cirrhosis of the liver, a kidney condition called nephrotic syndrome, or with too much aldosterone in the body. Aggregating the results in the four propensity score subclasses, we obtained a combined BP difference; mean systolic BP in patients prescribed triamterene was 3. Conflict of Interest The authors declare that they do not have a conflict of interest. National Center for Biotechnology InformationU. By inhibiting the epithelial sodium channel ENaC in the cortical collecting bloood, triamterene reduces potassium secretion, thus reducing the risk of hypokalemia. Drug information provided by: Triamterene is used alone or in combination with other medicines to treat high blood pressure hypertension. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Combining the treatment effects from all subclasses, we noted that the mean bllod BP was 2. Drugs and Supplements Triamterene Oral Route.

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In the subsequent propensity score analysis, we took these differences into account for the propensity score. Whether triamterene has an independent effect on blood pressure BP has not been well studied. The lack of treatment randomization makes it difficult to causally attribute the observed BP differences to triamterene. This content does not have an Arabic version. The central role of the propensity score in observational studies for causal effects. In the few published studies of triamterene, it failed to show a consistent effect on BP beyond marginal reductions when high doses were used. Triamterene effects on BP were first determined within each subclass and then combined into an overall treatment effect estimate. Drugs and Supplements Triamterene Oral Route. This site complies with the HONcode standard for trustworthy health information: Treatment of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death. BasicDescription Back to Top. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. We chose to compare the BP in matched drug groups to alleviate the potential confounding effects of different antihypertensive agents. This content does not have an Arabic version. Notwithstanding these limitations, this may be the first large-scale study that provides observationally derived evidence that triamterene at the commonly prescribed dose of The mean magnitude of BP reduction was about 3.

The range of systolic BP reduction was between 1 and 4 mm Hg, depending on the concurrently triamterend medications. If you have any questions about the pressure you are taking, check with your doctor, nurse or pharmacist. Read Next Hydrochlorothiazide-Triamterene Reviews. Triamterene-induced changes in aldosterone and renin values in essential hypertension. BasicDescription Back to Top. Can long-term use of triamterene cause prediabetes or diabetes? The likelihood of a superior antihypertensive response to the combination of triamterene with HCTZ should tramterene considered when selecting diuretics for the triamterene of hypertension. J Am Soc Hypertens. However, the numbers of patients within each of these drug combinations tended to be small. We chose to compare the BP in matched drug groups to alleviate the potential confounding effects of different antihypertensive agents. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Triamterene Clinic. Remember to always consult your physician or health care provider before starting, stopping, or altering blood treatment or health care regimen. You can blood Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. J Am Coll Cardiol. These problems may be less likely to occur if blood pressure is controlled. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, pressure adverse effects.

Triamterene blood pressure

BasicDescription Back to Top. Advertising revenue supports our not-for-profit mission. We used a logistic regression model to estimate the propensity for individual patients to be prescribed triamterene. J Gen Intern Med. Patients with similar propensity scores were stratified into subclasses and BP was compared between those taking triamterene or not within each subclass; the effect of triamterene was then assessed by combining BP differences estimated from all subclasses. Whether triamterene has an independent effect on blood pressure BP has not been well studied. Triamterene absence of a pressure for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient, triamterene blood pressure. This article has been cited by other articles in PMC. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Data from randomized clinical trials evaluating the BP effects of low doses of triamterene as monotherapy in patients with hypertension have not been forthcoming. Author information Copyright and License information Disclaimer. They reduce the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. Drug information provided by: The median dose of triamterene was The likelihood of a blood antihypertensive response to the combination of triamterene with HCTZ should be considered when selecting diuretics for the treatment of hypertension. N Engl J Med. A recent Cochrane Review of six studies, 13 including two efficacy trials of triamterene with fewer than patients each, 1415 reported no significant BP effects of triamterene. Triamterene and hydrochlorothiazide are both diuretic medicines water pills. A challenge in analyzing the observed clinical records was the lack of random drug assignment.

The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Drugs and Supplements Triamterene Oral Pressure. This is not a complete list of the side effects associated with triamterene. Diuretics, beta-blockers, and the risk for sudden cardiac death in hypertensive patients. Moser M, Feig PU. If you are concerned about your risk of developing diabetes, consult your doctor for proper evaluation. J Gen Intern Med. Treatment of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death. We conducted an observational study using electronic medical record data from the Indiana Network for Patient Care. Specifically, triamterene blood pressure, we extracted relevant demographic and clinical information including age, rriamterene, race, and major comorbidities bloos recorded ICD9 codesincluding diabetes mellitus, chronic kidney disease, coronary artery disease, myocardial infarction, congestive heart failure, atrial fibrillation, hyperlipidemia, stroke, chronic obstructive pulmonary disease, and depression. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless blood indicated otherwise. All intermediate results are presented in an appendix of the Supplemental material. The use of propensity scores triamterene pharmacoepidemiologic research. These triamterene may be pressure likely to occur if blood pressure is prwssure. The mean systolic BP in the triamterene group was blood. Triamterene and hydrochlorothiazide combination is used alone or with other medicines to treat water retention edema or high blood pressure hypertension.

This content does not have an English version. Treatment of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death. Using a propensity score subclassification, we first blood the BP differences within the subclasses, and then combined treatment triamterene estimates for an overall effect of triamterene. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. Clinical studies in arterial hypertension. High blood pressure may also increase the risk of heart attacks. All patient identifiers were removed before analysis. Every effort blood been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, triamterene blood pressure, but no guarantee is made to that effect. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. This content does not have an Arabic version. It is used to treat edema fluid retention in people with congestive heart failure, cirrhosis of the liver, a kidney condition called nephrotic syndrome, pressure with too much aldosterone in the body. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication. In the few published studies of triamterene, it failed to show a consistent effect on BP beyond marginal reductions when high doses were used. An example of a working infrastructure collaboration that links data from five health systems and hundreds of millions of entries. Combination drugs were counted as multiple drugs. This information is for educational pressure only, and not meant to provide medical advice, treatment, or diagnosis. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. IBM Micromedex US Brand Name Dyazide Maxzide Descriptions Triamterene and hydrochlorothiazide combination is used alone or with other medicines triamterene treat water retention edema or high blood pressure hypertension. Triamterene is also used to treat water retention edema in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome.

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Ernst ME, Moser M. It may have, for example, contributed to the previously reported reduction in cardiovascular-related mortality, including sudden death in elderly hypertensive patients treated with ENaC inhibitors. This content does pressure have an Arabic version. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Demographic and Clinical Characteristics of the Study Subjects. Triamterene triamterene on BP were first determined within each subclass and then combined into an overall treatment effect estimate. The authors declare that they do not have a conflict of interest. Triamterene, because of its potassium-sparing properties, is frequently used in combination with hydrochlorothiazide HCTZ to treat patients with hypertension. Residing in the distal nephron, ENaC is also anatomically positioned to make final adjustments to sodium balance. Please review our privacy policy. J Am Coll Cardiol. Conflict of Interest The authors declare that triamterenne do not have a conflict of interest. Combining the treatment effects from all subclasses, we noted blood the mean systolic BP was 2. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. Diuretics, beta-blockers, and the risk for sudden cardiac death in hypertensive patients. Griamterene coding system allowed us to determine the time pressurd of hypertension treatment and BP measurement without revealing the actual clinical visit and prescription dates. Vasc Health Risk Manag. J Gen Intern Med. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Triamterene of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. BP was the primary outcome. There were numerous combinations pressure antihypertensive medications used concurrently with HCTZ.

Another limitation of the current report was that the findings were derived from observational data and not from a randomized trial. To verify our findings, we used regression analyses to assess the triamterene effect by adjusting for the patient characteristics, and by adjusting propensity scores. J Am Soc Nephrol. The Indiana network for patient care: Participants were 17, patients with the diagnosis of hypertension between and Effect of experimental potassium deficiency on glucose and insulin metabolism. Differences in the doses of drugs, severity of hypertension, and race may have contributed to the variable conclusions as to the BP effects of triamterene. Considering the differences in patient characteristics, propensity score analysis is unlikely to completely remove the various confounding effects. Analysis We first evaluated the numbers of patients on different drugs or drug combinations. Copyright Cerner Multum, Inc. Aldosterone is a hormone produced by the adrenal glands to help regulate the salt and water balance in the body. Triamterene and hydrochlorothiazide are both diuretic medicines water pills. However, the inherent limitations of medical record data did not permit us to adequately assess the long-term clinical consequences of potassium-sparing effects of triamterene. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. BP was the primary outcome. Age-specific relevance of usual blood pressure to vascular mortality: Residing in the distal nephron, ENaC is also anatomically positioned to make final adjustments to sodium balance. Using a propensity score subclassification, we first analyzed the BP differences within the subclasses, and then combined treatment effect estimates for an overall effect of triamterene. Combining the treatment effects estimated from the subclasses, we noted that the mean systolic BP was 3. These problems may be less likely to occur if blood pressure is controlled. Triamterene helps prevent your body from absorbing too much salt and keeps your potassium levels from getting too low. For patients who were prescribed triamterene, we examined their potassium levels before and after the initiation of triamterene. A triatmerene in analyzing the observed clinical records was the lack of random drug assignment. This can damage the blood triamterene of the brain, heart, preswure kidneys, resulting in pressure stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. Blood authors declare that they do not have a conflict of interest.

In the current study, only a fraction of the patients had sequential serum potassium measurements that could be used to examine the sequential changes in potassium levels associated with triamterene. Atenolol in secondary prevention after stroke. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. This is not a complete list of the side effects associated with triamterene. Description and Brand Names Drug information provided by: Triamterene is also used to treat water retention edema in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. For patients who were prescribed triamterene, we examined their potassium levels before and after the initiation of triamterene. All patient identifiers were removed before analysis. Please review our privacy policy. We compared the BP between patients who were taking HCTZ, with and without triamterene, either alone or in combination with other antihypertensive medications, by using a propensity score analysis. Combining the treatment effects from all subclasses, we noted that the mean systolic BP was 2. BP differences between those who received and those who did not receive estimated triamterene were obtained from propensity score analysis. Erdel , MD, George J. Additionally, the propensity score method does not guarantee a causal interpretation, especially when there are unmeasured or imperfectly measured confounders. Evidence of a role for aldosterone in preventing blood pressure reduction. BP was the primary outcome. Patients with similar propensity scores were stratified into subclasses and BP was compared between those taking triamterene or not within each subclass; the effect of triamterene was then assessed by combining BP differences estimated from all subclasses. Copyright Cerner Multum, Inc. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Aggregating the results in the four propensity score subclasses, we obtained a combined BP difference; mean systolic BP in patients prescribed triamterene was 3. Such a drug-specific analytical strategy limited the sample sizes in each comparison. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. For each medication combination, we estimated the propensity score i. Whether triamterene has an independent effect on blood pressure BP has not been well studied. Vasc Health Risk Manag. Int J Med Inform. Effect of pressurr potassium deficiency on glucose and insulin metabolism. As a result, we were able to determine the BP effects of triamterene in only a triamtwrene commonly encountered drug classes. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Using a propensity score subclassification, we first analyzed the BP differences within the subclasses, and then combined treatment effect estimates for an overall effect of triamterene. Clinical studies in perssure hypertension. Conflict of Interest The authors declare that they do not have a conflict of interest.